Multiple endocrine neoplasia (MEN) II

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Multiple endocrine neoplasia, type II (MEN II) is disorder passed down through families in which one or more of the endocrine glands are overactive or form a tumor. Endocrine glands most commonly involved include:
  • Adrenal gland (about half the time)
  • Parathyroid gland  (20% of the time)
  • Thyroid gland (almost all of the time)
See also: MEN I

Causes

The cause of MEN II is a defect in a gene called RET. This defect causes many tumors to appear in the same person, but not necessarily at the same time.
A tumor in the adrenal gland is called a pheochromocytoma.
A tumor in the thyroid gland is a medullary carcinoma of the thyroid.
Tumors in the thyroid, adrenal, or parathyroid glands may occur years apart.
The disorder may occur at any age, and affects men and women equally. The main risk factor is a family history of MEN II.
There are two subtypes of MEN II -- MEN IIa and IIb. MEN IIb is less common.

Symptoms

The symptoms may vary. However, they are similar to those of:
  • Medullary carcinoma of the thyroid
  • Pheochromocytoma
  • Parathyroid adenoma
  • Parathyroid hyperplasia

Exams and Tests

To diagnose this condition, the health care provider looks for a mutation in the RET gene. This can be done with a blood test. Additional tests are done to determine which hormones are being overproduced.
A physical examination may reveal:
  • Enlarged lymph nodes in the neck
  • Fever
  • High blood pressure
  • Rapid heart rate
  • Thyroid nodules
Imaging tests used to identify tumors may include:
  • Abdominal CT scan
  • Imaging of the kidneys or ureters
  • MIBG scintiscan
  • MRI of abdomen
  • Thyroid scan
  • Ultrasound of the thyroid
Blood tests are used to see how well certain glands in the body are working. They may include:
  • Calcitonin level
  • Blood alkaline phosphatase
  • Blood calcium
  • Blood parathyroid hormone level
  • Blood phosphorus
  • Urine catecholamines
  • Urine metanephrine
Other tests or procedures that may be done include:
  • Adrenal biopsy
  • Electrocardiogram (ECG)
  • Thyroid biopsy
  • Parathyroid biopsy

Treatment

Surgery is needed to remove pheochromocytoma.
For medullary carcinoma of the thyroid, the thyroid gland and surrounding lymph nodes must be totally removed. Thyroid hormone replacement therapy is given after surgery.
If a child is known to carry the RET gene mutation, surgery to remove the thyroid before it becomes cancerous is considered. This should be discussed with a physician who is very familiar with this condition. It would be done at an early age (before age 5) in people with known MEN IIa, and before age 6 months in people with MEN IIb.

Outlook (Prognosis)

Pheochromocytoma is usually not cancerous (benign). Medullary carcinoma of the thyroid is a very aggressive and potentially fatal cancer. However, early diagnosis and surgery can often lead to a cure.

Possible Complications

The spread of cancerous cells is a possible complication.

When to Contact a Medical Professional

Call your health care provider if you notice symptoms of MEN II or if someone in your family receives such a diagnosis.

Prevention

Screening close relatives of people with MEN II may lead to early detection of the syndrome and related cancers.

Alternative Names

Sipple syndrome; MEN II

References

Kronenberg HM. Polyglandular disorders. In: Goldman L, Ausiello D, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011: chap 239.
National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: Neuroendocrine Tumors. National Comprehensive Cancer Network; 2011. Version 1. 2011.

Update Date: 3/14/2012

Updated by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.

Cancer - renal pelvis or ureter

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Cancer of the renal pelvis or ureter is cancer that forms in the kidney's pelvis or the tube that carries urine from the kidney to the bladder.

Causes

Cancer can grow in the urine collection system, but is uncommon. As a group, renal pelvis and ureter cancers account for about 5% of all cancers of the kidney and upper urinary tract. They affect men more often than women and are more common in people older than 65.
Tumors of the renal pelvis and ureter are usually transitional cell cancers. Approximately 10% are squamous cell carcinomas.
The causes of this cancer are not completely known. Long-term (chronic) irritation of the kidney from harmful substances removed in the urine may be a factor. This irritation may be caused by:
  • Analgesic nephropathy
  • Exposure to certain dyes and chemicals used to manufacture leather goods, textiles, plastics, and rubber
  • Smoking
Patients with a history of bladder cancer are also at risk.

Symptoms

  • Back pain, most often where ribs and spine meet
  • Bloody urine
  • Burning, pain, or discomfort with urination
  • Dark, rust-colored, or brown urine
  • Fatigue
  • Flank pain
  • Unintentional weight loss
  • Urinary frequency or urgency

Exams and Tests

The health care provider will perform a physical exam, and examine your belly area (abdomen). In rare cases, this may reveal an enlarged kidney.
The following tests may be done:
  • Abdominal CT scan
  • Chest x-ray
  • Cystoscopy with ureteroscopy
  • Intravenous pyelogram (IVP)
  • Kidney ultrasound
  • MRI of abdomen
  • Renal scan
These tests may reveal a tumor or show that the cancer has spread from the kidneys.

Treatment

The goal of treatment is to eliminate the cancer.
Surgery to remove all or part of the kidney (nephrectomy) is usually recommended. This may include removing part of the bladder and tissues around it, or the lymph nodes. If the tumor is in the ureter, it may be possible to remove it while preserving the kidney.
When the cancer has spread outside of the kidney or ureter, chemotherapy is often used. Because these tumors are similar to a form of bladder cancer, they are treated with a similar type of chemotherapy.

Support Groups

For additional information and resources, see cancer support groups.

Outlook (Prognosis)

The outcome varies depending on the location of the tumor and whether the cancer has spread. Cancer that is only in the kidney or ureter can be cured with surgery.
Cancer that has spread to other organs is usually not curable. However, there are exceptions.

Possible Complications

  • Kidney failure
  • Local spread of the tumor with increasing pain
  • Spread of the cancer

When to Contact a Medical Professional

Call your health care provider if you have the symptoms listed above.

Prevention

  • Follow your health care provider's advice regarding medications, including over-the-counter pain medicine.
  • Stop smoking.
  • Wear protective equipment if you may be exposed to substances that are toxic to the kidneys.

Alternative Names

Transitional cell cancer of the renal pelvis or ureter

References

Bajorin DF. Tumors of the kidney, bladder, ureters, and renal pelvis. In Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 203.
National Comprehensive Cancer Network. National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: Bladder cancer. 2012. Version 2.2012.

Abdominal aortic aneurysm repair - open

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Open abdominal aortic aneurysm repair is surgery to fix a widened part (aneurysm) in your aorta, the large artery that carries blood to your belly (abdomen), pelvis, and legs.
An aortic aneurysm is when part of this artery becomes too large or balloons outward.
Your surgeon opens up your belly and replaces the aortic aneurysm with a man-made, cloth-like material.

Description

The surgery will take place in an operating room. You will be given general anesthesia (you will be asleep and pain-free).
  • In one approach, you will lie on your back. The surgeon will make a cut in the middle of your belly, from just below the breastbone to below the navel. Rarely, the cut goes across the belly.
  • In another approach, you will lie slightly tilted on your right side. The surgeon will make a 5- to 6-inch cut from the left side of your belly, ending a little below your belly button.
  • Your surgeon will then replace the part of the aorta that has the aneurysm with a long tube graft. This tube graft is made from man-made (synthetic) cloth and is sewn in with sutures.
  • In some cases, the ends of the tube graft will be tunneled through each groin and attached to the leg vessels.
  • Once the surgery is done, your legs will be examined to make sure that there is a pulse.
  • The cut is closed with sutures or staples.
Surgery for aortic aneurysm replacement may take 2 to 4 hours. Most patients recover in the intensive care unit (ICU) after the surgery.
See also: Aortic aneurysm repair - endovascular

Why the Procedure is Performed

Open surgery to repair an abdominal aortic aneurysm is sometimes done as an emergency procedure when there is any bleeding inside your body from the aneurysm.
You may also have an abdominal aortic aneurysm that is not causing any symptoms or problems. Your doctor may have found out about this problem from tests called ultrasound or CT scan. There is a risk that this aneurysm may suddenly break open (rupture) if you do not have surgery to repair it. However, surgery to repair the aneurysm may also be risky, depending on your overall health.
You and your doctor must decide whether the risk of having this surgery is smaller than the risk of rupture if you do not have the surgery. The doctor is more likely to recommend surgery if the aneurysm is:
  • Larger (about 2 inches or 5 cm)
  • Growing more quickly (a little less than 1/4 inch over the last 6 to 12 months)

Risks

The risks for this surgery are higher if you have:
  • Heart disease
  • Kidney failure
  • Lung disease
  • Past stroke
  • Other serious medical problems
Risks of problems or complications are also higher for older people.
Risks for any surgery are:
  • Blood clots in the legs that may travel to the lungs
  • Breathing problems
  • Heart attack or stroke
  • Infection, including in the lungs (pneumonia), urinary tract, and belly
  • Reactions to medicines
Risks for this surgery are:
  • Bleeding before or after surgery
  • Damage to a nerve, causing pain or numbness in the leg
  • Damage to your intestines or other nearby organs
  • Infection of the graft
  • Injury to the ureter, the tube that carries urine from your kidneys to your bladder
  • Lower sex drive or inability to get an erection
  • Poor blood supply to your legs, your kidneys, or other organs
  • Spinal cord injury
  • Wound breaks open
  • Wound infections

Before the Procedure

Your doctor will do a thorough physical exam and tests before you have surgery.
Always tell your doctor or nurse what drugs you are taking, even drugs, supplements, or herbs you bought without a prescription.
If you are a smoker, you should stop smoking at least 4 weeks before your surgery. Your doctor or nurse can help.
During the 2 weeks before your surgery:
  • You will have visits with your doctor to make sure medical problems such as diabetes, high blood pressure, and heart or lung problems are being treated well.
  • You may be asked to stop taking drugs that make it harder for your blood to clot. These include aspirin, ibuprofen (Advil, Motrin), clopidogrel (Plavix), naprosyn (Aleve, Naproxen), and other drugs like these.
  • Ask your doctor which drugs you should still take on the day of your surgery.
  • Always let your doctor know about any cold, flu, fever, herpes breakout, or other illness you may have before your surgery.
Do NOT drink anything after midnight the day before your surgery, including water.
On the day of your surgery:
  • Take the drugs your doctor told you to take with a small sip of water.
  • Your doctor or nurse will tell you when to arrive at the hospital.

After the Procedure

Most people stay in the hospital for 5 to 10 days. During a hospital stay, you will:
  • Be in the intensive care unit (ICU), where you will be monitored very closely right after surgery. You may need a breathing machine during the first day.
  • Have a urinary catheter
  • Have a tube that goes through your nose into your stomach to help drain fluids for 1 or 2 days. You will then slowly begin drinking, then eating.
  • Receive medicine to keep your blood thin
  • Be encouraged to sit on the side of the bed and then walk
  • Wear special stockings to prevent blood clots in your legs
  • Be asked to use a breathing machine to help clear your lungs
  • Receive pain medicine into your veins or into the space that surrounds your spinal cord (epidural)

Outlook (Prognosis)

Full recovery for open surgery to repair an aortic aneurysm may take 2 or 3 months. Most people make a full recovery from this surgery.
Most people who have an aneurysm repaired before it breaks open (ruptures) have a good outlook.

Alternative Names

AAA - open; Repair - aortic aneurysm - open

References

Gloviczki P, Ricotta JJ II. Aneurysmal vascular disease. In: Townsend CM, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 18th ed. Philadelphia, Pa: Saunders Elsevier; 2008:chap 65.
De Bruin JL, Baas AF, Buth J, Brinssen M, Verhoeven EL, Cuypers PW, et al: DREAM Study Group. Long-term outcome of open or endovascular repair of abdominal aortic aneurysm. N Engl J Med; 2010:362:1881-1889.
United Kingdom EVAR Trial Investigators, Grenhalgh RM, Brown LC, Powell JT, Thompson SG, Epstein D, Sculpher MJ. Endovascular versus open repair of abdominal aortic aneurysm. N Engl J Med; 2010;362:1863-1871.

Abdominal aortic aneurysm repair - open - discharge

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You had open aortic aneurysm surgery to repair an aneurysm (a widened part) in your aorta, the large artery that carries blood to your belly (abdomen), pelvis, and legs.
You have a long incision (cut) either in the middle of your belly or on the left side of your belly. Your surgeon repaired your aorta through this incision. After spending 1 to 3 days in the intensive care unit (ICU), you spent more time recovering in a regular hospital room.

What to Expect at Home

Plan to have someone drive you home from the hospital. Do NOT drive yourself home.
You should be able to do most of your regular activities in 4 to 8 weeks. Before that:
  • Do not lift anything heavier than 10 to 15 pounds until you see your doctor.
  • Avoid all strenuous activity. This includes heavy exercising, weightlifting, and other activities that make you breathe hard or strain.
  • Short walks and using stairs are okay.
  • Light housework is okay.
  • Don't push yourself too hard. Increase how much you exercise slowly.

Managing Pain

Your doctor will prescribe pain medicines to use at home. If you are taking pain pills 3 or 4 times a day, try taking them at the same times each day for 3 to 4 days. They may be more effective this way.
Try getting up and moving around if you are having some pain in your belly. This may ease your pain.
Press a pillow over your incision when you cough or sneeze to ease discomfort and protect your incision.
Make sure your home is safe as you are recovering.
See also:

Wound Care

Change the dressing over your surgical wound once a day, or sooner if it becomes soiled. Your doctor will tell you when you do not need to keep your wound covered. Keep the wound area clean. You may wash it with mild soap and water if your doctor says you can. See also: Surgical wound care
You may remove the wound dressings and take showers if sutures, staples, or glue were used to close your skin if your doctor says you can.
If tape strips (Steri-strips) were used to close your incision, cover the incision with plastic wrap before showering for the first week. Do not try to wash off the Steri-strips or glue.
Do not soak in a bathtub or hot tub, or go swimming, until your doctor tells you it is okay.

Lifestyle Changes

Surgery will not cure the cause of your aneurysm. Your arteries may become widened again, or you may have this problem in another artery. You will need to make lifestyle changes to try to prevent the problem from coming back:
  • Eat a heart-healthy diet, exercise, stop smoking (if you smoke), and reduce stress to help lower your chances of having a blocked artery again.
  • Your health care provider may give you medicine to help lower your cholesterol. See also: Cholesterol - drug treatment
  • If you were given medicines for blood pressure or diabetes, take them as your doctor has asked you to.

When to Call the Doctor

Call your doctor or nurse if:
  • You have pain in your belly or back that does not go away or is very bad.
  • Your legs are swelling.
  • You have chest pain or shortness of breath that does not go away with rest.
  • You have dizziness, fainting, or you are very tired.
  • You are coughing up blood or yellow or green mucus.
  • You have chills or a fever over 100.5 °F.
  • Your belly hurts or feels distended.
  • There are changes in your surgical incision:
    • The edges are pulling apart.
    • You have green or yellow drainage.
    • You have more redness, pain, warmth, or swelling.
    • Your bandage is soaked with blood.
  • Your legs are swelling.
  • You have blood in your stools.
  • You are not able to move your legs.

Alternate Names

AAA - open - discharge; Repair - aortic aneurysm - open - discharge

References

De Bruin JL, Baas AF, Buth J, Prinssen M, Verhoeven EL, Cuypers PW, van Sambeek MR, Balm R, Grobbee DE, Blankensteijn JD; DREAM Study Group. Long-term outcome of open or endovascular repair of abdominal aortic aneurysm. N Engl J Med. 2010 May 20;362(20):1881-9.
Gloviczki P, Ricotta JJ II. Aneurysmal vascular disease. In: Townsend CM, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 18th ed. Philadelphia, Pa: Saunders Elsevier; 2008:chap 65.
Greenhalgh RM, Powell JT. Endovascular repair of abdominal aortic aneurysm. N Engl J Med. 2008 Jan 31;358(5):494-501.
Lederle FA, Kane RL, MacDonald R, Wilt TJ. Systematic review: repair of unruptured abdominal aortic aneurysm. Ann Intern Med. 2007 May 15;146(10):735-41.

Thoracic aortic aneurysm

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An aneurysm is an abnormal widening or ballooning of a portion of an artery due to weakness in the wall of the blood vessel.
A thoracic aortic aneurysm occurs in the part of the body's largest artery (the aorta) that passes through the chest.

Causes

The most common cause of a thoracic aortic aneurysm is hardening of the arteries (atherosclerosis). This condition is more common in people with high cholesterol, long-term high blood pressure, or who smoke.
Other risk factors for a thoracic aneurysm include:
  • Changes caused by age
  • Connective tissue disorders such as Marfan syndrome
  • Inflammation of the aorta
  • Injury from falls or motor vehicle accidents
  • Syphilis

Symptoms

Aneurysms develop slowly over many years. Most patients have no symptoms until the aneurysm begins to leak or expand. The aneurysm may be found only when imaging tests are done for other reasons.
Symptoms often begin suddenly when:
  • The aneurysm grows quickly
  • The aneurysm tears open (called a rupture)
  • Blood leaks along the wall of the aorta (aortic dissection)
If the aneurysm presses on nearby structures, the following symptoms may occur:
  • Hoarseness
  • Swallowing problems
  • High-pitched breathing (stridor)
  • Swelling in the neck
Other symptoms may include:
  • Chest or upper back pain
  • Clammy skin
  • Nausea and vomiting
  • Rapid heart rate
  • Sense of impending doom

Exams and Tests

The physical examination is often normal unless a rupture or leak has occurred.
Most thoracic aortic aneurysms are detected by tests performed for other reasons, usually a chest x-ray, echocardiogram, or a chest CT scan or MRI. A chest CT scan shows the size of the aorta and the exact location of the aneurysm.
An aortogram (a special set of x-ray images made when dye is injected into the aorta) can identify the aneurysm and any branches of the aorta that may be involved.

Treatment

There is a risk that the aneurysm may open up (rupture) if you do not have surgery to repair it.
The treatment depends on the location of the aneurysm. The aorta is made of three parts:
  • The first part moves upward towards the head. It is called the ascending aorta.
  • The middle part is curved. It is called the aortic arch.
  • The last part moves downward, toward the feet. It is called the descending aorta.
For patients with aneurysms of the ascending aorta or aortic arch:
  • Surgery to replace the aorta is recommended if an aneurysm is larger than 5 - 6 centimeters.
  • A cut is made in the middle of the chest bone.
  • The aorta is replaced with a plastic or fabric graft.
  • This is major surgery that requires a heart-lung machine.
For patients with aneurysms of the descending thoracic aorta:
  • Majory surgery is done to replace the aorta with a fabric graft if the aneurysm is larger than 6 centimeters.
  • This surgery is done through a cut on the left side of the chest, which may reach to the abdomen.
  • Endovascular stenting is a less invasive option. A stent is a tiny metal or plastic tube that is used to hold an artery open. Stents can be placed into the body without cutting the chest. Not all patients with descending thoracic aneurysms are candidates for stenting, however.

Outlook (Prognosis)

The long-term outlook for patients with thoracic aortic aneurysm depends on other medical problems, such as heart disease, high blood pressure, and diabetes, which may have caused or contributed to the condition.

Possible Complications

Serious complications after aortic surgery can include:
  • Bleeding
  • Graft infection
  • Heart attack
  • Irregular heartbeat
  • Kidney damage
  • Paralysis
  • Stroke
Death soon after the operation occurs in 5 - 10% of patients.
Complications after aneurysm stenting include damage to the blood vessels supplying the leg, which may require another operation.

When to Contact a Medical Professional

Tell your doctor if you have:
  • A family history of connective tissue disorders (such as Marfan syndrome)
  • Chest or back discomfort

Prevention

To prevent atherosclerosis:
  • Control your blood pressure and blood lipid levels.
  • Do not smoke.
  • Eat a healthy diet.
  • Exercise regularly.

Alternative Names

Aortic aneurysm - thoracic; Syphilitic aneurysm; Aneurysm - thoracic aortic

References

Tracci MC, Cherry KJ. The aorta. In: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL. Sabiston Textbook of Surgery. 19th ed. Philadelphia, Pa: Saunders Elsevier; 2012:chap 62.
Cheng D, Martin J, Shennib H, et al. Endovascular aortic repair versus open surgical repair for descending thoracic aortic disease: a systematic review and meta-analysis of comparative studies. J Am Coll Cardiol. 2010:55(10):986-1001.
Isselbacher EM. Diseases of the aorta. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 78.

Aneurysm in the brain

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An aneurysm is a weak area in the wall of a blood vessel that causes the blood vessel to bulge or balloon out. When an aneurysm occurs in a blood vessel of the brain, it is called a cerebral aneurysm.

Causes

Aneurysms in the brain occur when there is a weakened area in the wall of a blood vessel. An aneurysm may be present from birth (congenital) or it may develop later in life, such as after a blood vessel is injured.
There are many different types of aneurysms. A berry aneurysm can vary in size from a few millimeters to over a centimeter. Giant berry aneurysms can reach well over 2 centimeters. These are more common in adults. Multiple berry aneurysms are inherited more often than other types of aneurysms.
Other types of cerebral aneurysm involve widening of an entire blood vessel, or they may appear as a "ballooning out" of part of a blood vessel. Such aneurysms can occur in any blood vessel that supplies the brain. Atherosclerosis, trauma, and infection, which can injure the blood vessel wall, can cause cerebral aneurysms.
About 5% of the population has some type of aneurysm in the brain, but only a small number of these aneurysms cause symptoms or rupture. Risk factors include a family history of cerebral aneurysms, and certain medical problems such as polycystic kidney disease, coarctation of the aorta, and high blood pressure.

Symptoms

A person may have an aneurysm without having any symptoms. This kind of aneurysm may be found when an MRI or CT scan of the brain is done for another reason.
A cerebral aneurysm may begin to "leak" a small amount of blood. This may cause a severe headache that a patient may describe as "the worst headache of my life." Another phrase used to describe this is a sentinel headache. This means the headache could be a warning sign of a rupture days or weeks after the headache first happens.
Symptoms may also occur if the aneurysm pushes on nearby structures in the brain or breaks open (ruptures) and causes bleeding into the brain.
Symptoms depend on the location of the aneurysm, whether it breaks open, and what part of the brain it is pushing on, but they may include:
  • Double vision
  • Loss of vision
  • Headaches
  • Eye pain
  • Neck pain
  • Stiff neck
A sudden, severe headache is one symptom of an aneurysm that has ruptured. Other symptoms of an aneurysm rupture may include:
NOTE: A ruptured aneurysm is a medical emergency. Seek immediate medical help.

Exams and Tests

An eye exam may show evidence of increased pressure in the brain (raised intracranial pressure), including swelling of the optic nerve or bleeding into the retina of the eye. A brain and nervous system (neurological) exam may show abnormal eye movement, speech, strength, or sensation.
The following tests may be used to diagnose cerebral aneurysm and determine the cause of bleeding in the brain:

Treatment

Two common methods are used to repair an aneurysm:
  • Clipping is the most common way to repair an aneurysm. This is done during open brain surgery. See also: Brain surgery (craniotomy)
  • Endovascular repair, most often using a "coil" or coiling, is a less invasive way to treat some aneurysms.
If an aneurysm in the brain ruptures, it is an emergency that needs medical treatment and often requires surgery. Endovascular repair is more often used when this happens.
Even if there are no symptoms, your doctor may order treatment to prevent a future, possibly fatal, rupture.
Not all aneurysms need to be treated right away. Those that are very small (less than 3 mm) are less likely to break open.
Your doctor will help you decide whether it is safer to have surgery to block off the aneurysm before it can break open (rupture).
Someone may be too ill to have surgery, or it may be too dangerous to treat the aneurysm because of its location.
Treatment may involve:
  • Complete bedrest and activity restrictions
  • Drugs to prevent seizures
  • Medicines to control headaches and blood pressure
Once the aneurysm is repaired, prevention of stroke from blood vessel spasm may be necessary. This may include intravenous fluids, certain medications, and letting the blood pressure get high.

Outlook (Prognosis)

The outcome varies. Patients who are in deep comas after an aneurysm rupture generally do not do as well as those with less severe symptoms.
Ruptured cerebral aneurysms are often deadly. About 25% of people die within 1 day, and another 25% die within about 3 months. Of those who survive, about 25% will have some sort of permanent disability.

Possible Complications

  • Increased pressure inside the skull
  • Loss of movement in one or more parts of the body
  • Loss of sensation of any part of the face or body
  • Seizures
  • Stroke
  • Subarachnoid hemorrhage

When to Contact a Medical Professional

Go to the emergency room or call the local emergency number (such as 911) if you have a sudden or severe headache, especially if you also have nausea, vomiting, seizures, or any other neurological symptoms.
Also call if you have a headache that is unusual for you, especially if it is severe or your worst headache ever.

Prevention

There is no known way to prevent the formation of a berry aneurysm. Treating high blood pressure may reduce the chance that an existing aneurysm will rupture. Controlling risk factors for atherosclerosis may reduce the likelihood of some types of aneurysms.
If unruptured aneurysms are discovered in time, they can be treated before causing problems.
The decision to repair an unruptured cerebral aneurysm is based on the size and location of the aneurysm, and the patient's age and general health. The risks involved in both operating and watchful waiting must be carefully considered.

Alternative Names

Aneurysm - cerebral; Cerebral aneurysm

References

Bederson JB, Connolly ES Jr, Batjer HH, Dacey RG, Dion JE, Diringer MN, Duldner JE Jr, Harbaugh RE, Patel AB, Rosenwasser RH: American Heart Association Guidelines for the management of aneurysmal subarachnoid hemorrhage: a statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Stroke. 2009;40:994-1025.
Meyers PM, Schumacher HC, Higashida RT, Barnwell SL, Creager MA, Gupta R, McDougall CG, Pandey DK, Sacks D, Wechsler JR: American Heart Association. Indications for the performance of intracranial endovascular neurointerventional procedures: a scientific statement from the American Heart Associatino Council on Cardiovascular Radiology and Intervention. Stroke Council, council on Cardiovascular Surgery and Anesthesia, Interdisciplinary Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research. Circulation. 2009;119:2235-2249.
Patterson JT, Hanbali F, Franklin RL, Nauta HJW. Neurosurgery. In: Townsend CM, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 18th ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 72.

Abdominal aortic aneurysm

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An abdominal aortic aneurysm is when the large blood vessel that supplies blood to the abdomen, pelvis, and legs becomes abnormally large or balloons outward.

Causes

The exact cause is unknown, but risk factors for developing an aortic aneurysm include:
  • Smoking
  • High blood pressure
  • High cholesterol
  • Male gender
  • Emphysema
  • Genetic factors
  • Obesity
An abdominal aortic aneurysm can develop in anyone, but is most often seen in males over 60 who have one or more risk factors. The larger the aneurysm, the more likely it is to rupture and break open.

Symptoms

Aneurysms develop slowly over many years and often have no symptoms. If an aneurysm expands rapidly, tears open (ruptured aneurysm), or blood leaks along the wall of the vessel (aortic dissection), symptoms may develop suddenly.
The symptoms of rupture include:
  • Pain in the abdomen or back -- severe, sudden, persistent, or constant. The pain may radiate to the groin, buttocks, or legs.
  • Clammy skin
  • Nausea and vomiting
  • Rapid heart rate
  • Shock

Exams and Tests

Your doctor will examine your abdomen. The exam also will include an evaluation of pulses and feeling in your legs. The doctor may find:
  • A lump (mass) in the abdomen
  • Pulsating sensation in the abdomen
  • Stiff or rigid abdomen
You may have an abdominal aortic aneurysm that is not causing any symptoms or problems. Your doctor may find this problem by doing the following tests:
  • CT scan of the abdomen
  • Ultrasound of the abdomen
Either of these tests may be done when you're having symptoms.

Treatment

If you have bleeding inside your body from an aortic aneurysm, you will have open abdominal aortic aneurysm repair.
If the aneurysm is small and there are no symptoms:
  • You and your doctor must decide whether the risk of having surgery is smaller than the risk of bleeding if you do not have surgery.
  • Your doctor may recommend checking the size of the aneurysm with ultrasound tests every 6 months to see if the aneurysm is getting bigger.
Surgery is usually recommended for patients who have aneurysms bigger than 2 inches (5.5 cm) across and aneurysms that are growing quickly. The goal is to perform surgery before complications or symptoms develop.
There are two approaches to surgery:
  • In a traditional (open) repair, a large cut is made in your abdomen. The abnormal vessel is replaced with a graft made of man-made material, such as Dacron.
  • The other approach is called endovascular stent grafting. This procedure can be done without making a large cut in your abdomen, so you may get well faster. If you have certain other medical problems, this may be a safer approach. Endovascular repair is rarely done for a leaking or bleeding aneurysm.

Outlook (Prognosis)

The outcome is usually good if an experienced surgeon repairs the aneurysm before it ruptures. However, less than 80% of patients survive a ruptured abdominal aneurysm.

Possible Complications

When an abdominal aortic aneurysm ruptures, it is a true medical emergency. Aortic dissection occurs when the innermost lining of the artery tears and blood leaks into the wall of the artery. This most commonly occurs in the aorta within the chest.
Complications include:
  • Arterial embolism
  • Heart attack
  • Hypovolemic shock
  • Kidney failure
  • Stroke

When to Contact a Medical Professional

Go to the emergency room or call 911 if you have pain in your belly or back that does not go away or is very bad.

Prevention

To reduce the risk of developing aneurysms:
  • Eat a heart-healthy diet, exercise, stop smoking (if you smoke), and reduce stress to help lower your chances of having a blocked artery again.
  • Your health care provider may give you medicine to help lower your cholesterol.
  • If you were given medicines for blood pressure or diabetes, take them as your doctor has asked you to.
People over age 65 who have smoked at any time in their life should have a screening ultrasound performed once.

Alternative Names

Aneurysm - aortic; AAA

References

Gloviczki P, Ricotta JJ II. Aneurysmal vascular disease. In: Townsend CM, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 18th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 65.
Greenhalgh RM, Powell JT. Endovascular repair of abdominal aortic aneurysm. N Engl J Med. 2008;358:494-501.
Lederle FA, Kane RL, MacDonald R, Wilt TJ. Systematic review: repair of unruptured abdominal aortic aneurysm. Ann Intern Med. 2007;146:735-741.
Braverman AC, Thompson RW, Sanchez LA. Diseases of the aorta. In: Bonow RO, Mann DL, Zipes DP, Libby P, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 60.